细胞膜连接的通透性。对能量代谢的依赖性。
Permeability of a cell membrane junction. Dependence on energy metabolism.
作者信息
Politoff A L, Socolar S J, Loewenstein W R
出版信息
J Gen Physiol. 1969 Apr;53(4):498-515. doi: 10.1085/jgp.53.4.498.
Abstract
The ion permeability of the membrane junctions between Chironomus salivary gland cells is strongly depressed by treatments that are generally known to inhibit energy metabolism. These treatments include prolonged cooling at 6 degrees -8 degrees C, and exposure to dinitrophenol, cyanide, oligomycin, and N-ethylmaleimide. Intracellular injection of ATP appears to prevent depression of junctional permeability by dinitrophenol or to reverse it. Ouabain, azide, p-chloromercuriphenylsulfonic acid, reserpine, and acetazolamide fail to depress junctional permeability. Thus the ion permeability of the junctional membranes appears to depend on energy provided by oxidative phosphorylation. Possible energy-linked processes for maintaining junctional permeability are discussed, including processes involving transport of permeability-modifying species such as Ca(++).
摘要
摇蚊唾液腺细胞间膜连接的离子通透性会因一些普遍认为能抑制能量代谢的处理而受到强烈抑制。这些处理包括在6摄氏度至8摄氏度下长时间冷却，以及暴露于二硝基苯酚、氰化物、寡霉素和N - 乙基马来酰亚胺。细胞内注射ATP似乎能防止二硝基苯酚引起的连接通透性降低或使其逆转。哇巴因、叠氮化物、对氯汞苯磺酸、利血平和乙酰唑胺未能降低连接通透性。因此，连接膜的离子通透性似乎取决于氧化磷酸化提供的能量。文中讨论了维持连接通透性的可能的能量相关过程，包括涉及诸如钙离子等通透性调节物质运输的过程。
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