抗醛固酮化合物对大鼠心肌坏死可能的保护作用。
Possible protective action of antialdosterone compounds in myocardial necrosis in rats.
作者信息
Moudgil L R
出版信息
Br J Pharmacol. 1969 Mar;35(3):558-62. doi: 10.1111/j.1476-5381.1969.tb08296.x.
Abstract
- Experimental myocardial necrosis was produced in rats by injection of large doses of isoprenaline.2. The effectiveness of four aldosterone antagonists in preventing this myocardial necrosis was studied.3. The relative effectiveness of these compounds in preventing isoprenaline-induced necrosis was found to be Sc 5233>Sc 9420 (spironolactone)>Sc 11927 and Sc 8109.4. The reported relative effectiveness of these compounds as aldosterone antagonists is Sc 11927>Sc 9420, Sc 8109>Sc 5233.5. The significance of these findings is discussed.
摘要
通过注射大剂量异丙肾上腺素在大鼠身上造成实验性心肌坏死。
研究了四种醛固酮拮抗剂预防这种心肌坏死的有效性。
发现这些化合物在预防异丙肾上腺素诱导的坏死方面的相对有效性为Sc 5233>Sc 9420（螺内酯）>Sc 11927和Sc 8109。
报道的这些化合物作为醛固酮拮抗剂的相对有效性为Sc 11927>Sc 9420，Sc 8109>Sc 5233。
讨论了这些发现的意义。
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