Cytogenetic studies in rats of cyclohexylamine, a metabolite of cyclamate.

Cyclohexylamine, the major known metabolite of cyclamate, was tested in vivo for possible cytogenetic effects. In rats injected with this metabolite, there was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks. Single chromatid breaks predominated with infrequent exchange figures.