氨溴索对慢性支气管肺部疾病的治疗研究（作者译）
[Therapeutic study on ambroxol in chronic bronchopulmonary diseases (author's transl)].
作者信息
Curti P C, Renovanz H D
出版信息
Arzneimittelforschung. 1978;28(5a):922-5.
The clinical activity of trans-4-[(2-amino-3,5-dibromo-benzyl)-amino]-cyclohexanol-hydrochloride (ambroxol, NA 872) as well as its influence on lung function was examined in a total of 63 patients (34 suffering from silicosis, 28 from chronic obstructive bronchitis and 1 from cryptococcosis). Additionally, the content of phospholipids was controlled in the sputum of the patient group. It was shown that the activity of ambroxol was better in the silicosis group than in the bronchitis group. The cause was discussed. Presumably the twofold site of action in the silicosis group (secretolysis and surfactant stimulation) might be the reason for this.
对63例患者（34例矽肺患者、28例慢性阻塞性支气管炎患者和1例隐球菌病患者）进行了反式-4-[(2-氨基-3,5-二溴苄基)-氨基]-环己醇盐酸盐（氨溴索，NA 872）的临床活性及其对肺功能影响的研究。此外，还对患者组痰液中的磷脂含量进行了检测。结果表明，氨溴索在矽肺组的活性优于支气管炎组。对其原因进行了讨论。推测矽肺组的双重作用位点（促分泌作用和表面活性剂刺激作用）可能是造成这种情况的原因。
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