潜在的抗肿瘤药。第四次通讯：雌酮的N-芥子气衍生物
Potential antineoplastics. 4th communication: N-mustard derivatives of estrone).
作者信息
Hamacher H
出版信息
Arzneimittelforschung. 1979;29(3):463-6.
PMID:582728
Abstract
The nitrogen mustards 5 and 9 are synthesized as potential mammatropic antineoplastic agents from estrone via 2--4 or 6--8, respectively. 5 and 9 show a binding affinity to the cytoplasmic estrogen receptor of the rat uterus of 1--10% compared to that of estrone. Both mustard compounds are irreversibly bound to the estrogen receptor.
摘要
氮芥5和9分别通过2-4或6-8由雌酮合成，作为潜在的促乳腺抗肿瘤剂。与雌酮相比，5和9对大鼠子宫细胞质雌激素受体的结合亲和力为1%-10%。两种氮芥化合物均与雌激素受体不可逆结合。
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