Lopes O U, Palmer J F
Q J Exp Physiol Cogn Med Sci. 1977 Jan;62(1):41-53. doi: 10.1113/expphysiol.1977.sp002375.
Electrical stimulation of the "Defence Area" of the hypothalamus in anaesthetized cats was accomplished by stereotaxic placement of bipolar stainless steel electrodes; the spinal cord was sectioned at L4. The muscle blood flow in one hind limb was recorded with an electromagnetic flowmeter. Increases of between 100% and 300% were observed during hypothalamic stimulation. Electroneurographic recordings from small nerve filaments supplying tibialis anterior muscle revealed two populations of neurones whose activity was abolished by lumbar sympathectomy. It appears that the increased blood flow in skeletal muscle during stimulation of the hypothalamic "Defence Area" is brought about by a simultaneous inhibition of vasoconstrictor activity and increase in cholinergic vasodilator discharge.
通过立体定位将双极不锈钢电极置于麻醉猫的下丘脑“防御区”进行电刺激；脊髓在L4水平横断。用电磁流量计记录一侧后肢的肌肉血流。下丘脑刺激期间观察到血流量增加了100%至300%。对供应胫骨前肌的小神经纤维进行的神经电图记录显示，有两类神经元，其活动可被腰交感神经切除术消除。看来，刺激下丘脑“防御区”时骨骼肌血流量增加是由于血管收缩活动同时受到抑制以及胆碱能血管舒张神经放电增加所致。
