卵巢切除术对可移植性子宫肿瘤核糖核酸代谢的影响。
The effect of oophorectomy on the ribonucleic acid metabolism of a transplantable uterine tumour.
作者信息
Mainwaring W I, Williams D C
出版信息
Biochem J. 1965 Dec;97(3):609-14. doi: 10.1042/bj0970609.
Abstract
- The incorporation of [(14)C]phenylalanine and of [(3)H]uridine into the Guerin T8 uterine carcinoma has been examined. 2. The addition in vitro of polyuridylic acid caused an increase in the incorporation of labelled phenylalanine into tumour microsomes obtained from both oophorectomized and intact animals. 3. Oophorectomy of tumour-bearing animals decreased the specific activity due to the uptake in vivo of [(3)H]uridine into both the soluble and insoluble RNA of the tumour. 4. Actinomycin D caused a decrease in specific activity of RNA in the tumour in vivo, and puromycin inhibited uptake in vitro into tumour microsomes.
摘要
- 已检测了[(14)C]苯丙氨酸和[(3)H]尿苷掺入格林T8子宫癌的情况。2. 在体外添加多聚尿苷酸会使从去卵巢和未去卵巢动物获得的肿瘤微粒体中标记苯丙氨酸的掺入量增加。3. 荷瘤动物去卵巢会降低因[(3)H]尿苷在体内摄取进入肿瘤的可溶性和不溶性RNA而导致的比活性。4. 放线菌素D会使体内肿瘤中RNA的比活性降低，嘌呤霉素会抑制体外肿瘤微粒体的摄取。
相似文献
1
The effect of oophorectomy on the ribonucleic acid metabolism of a transplantable uterine tumour.
Biochem J. 1965 Dec;97(3):609-14. doi: 10.1042/bj0970609.
2
The effect of castration on the ribonucleic acid metabolism of an experimental prostatic tumour.
Biochem J. 1966 Mar;98(3):836-40. doi: 10.1042/bj0980836.
3
4
Ribonucleic acid synthesis during the early action of thyroid hormones.
Biochem J. 1966 Feb;98(2):604-20. doi: 10.1042/bj0980604.
5
Relationship between uridine kinase activity and rate of incorporation of uridine into acid-soluble pool and into RNA during growth cycle of rat hepatoma cells.
J Cell Physiol. 1969 Jun;73(3):233-49. doi: 10.1002/jcp.1040730308.
6
7
Increase of RNA synthesis during mammary tumor regression.
Cancer Res. 1974 Apr;34(4):751-7.
8
Inhibition by actinomycin D of oxidation-dependent biosynthesis in Sarcoma 37 ascites cells.
J Biol Chem. 1966 Apr 25;241(8):1681-7.
9
Turnover of messenger ribonucleic acid and protein biosynthesis in the mouse mammary adenocarcinoma H2712.
Biochemistry. 1965 Aug;4(8):1678-86. doi: 10.1021/bi00884a034.
10
Adrenal cells in tissue culture. VII. The effect of inhibitors of protein synthesis on steroidogenesis and glycolysis.
Endocrinology. 1970 Nov;87(5):951-65. doi: 10.1210/endo-87-5-951.
引用本文的文献
1
The effect of castration on the ribonucleic acid metabolism of an experimental prostatic tumour.
Biochem J. 1966 Mar;98(3):836-40. doi: 10.1042/bj0980836.
本文引用的文献
1
Electron Microscope Studies of Ribosomal Clusters Synthesizing Hemoglobin.
Science. 1962 Dec 28;138(3548):1399-403. doi: 10.1126/science.138.3548.1399.
2
POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA.
Proc Natl Acad Sci U S A. 1963 May;49(5):654-62. doi: 10.1073/pnas.49.5.654.
3
INHIBITION BY PUROMYCIN OF AMINO ACID INCORPORATION INTO PROTEIN.
Proc Natl Acad Sci U S A. 1959 Dec;45(12):1721-9. doi: 10.1073/pnas.45.12.1721.
4
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75.
5
Action of actinomycin D on animal cells and viruses.
Proc Natl Acad Sci U S A. 1962 Jul 15;48(7):1238-45. doi: 10.1073/pnas.48.7.1238.
6
Preparation and amino acid incorporating ability of ribonucleoprotein-particles from different tissues of the rat.
Exp Cell Res. 1960 Mar;19:253-66. doi: 10.1016/0014-4827(60)90006-9.
7
RECOGNITION OF ALTERED PATTERNS OF MESSENGER RNA SYNTHESIS IN A MOUSE HEPATOMA.
Cancer Res. 1964 Oct;24:1604-9.
8
THE BINDING OF ESTRADIOL IN THE UTERUS: A MECHANISM FOR DEPRESSION OF RNA SYNTHESIS.
Proc Natl Acad Sci U S A. 1964 Oct;52(4):1059-66. doi: 10.1073/pnas.52.4.1059.
9
EFFECTS OF ALTERATIONS IN HORMONAL STATUS ON RIBOSOMES OF RAT UTERUS.
Arch Biochem Biophys. 1964 Jul;107:1-6. doi: 10.1016/0003-9861(64)90261-9.
10
ESTROGEN-INDUCED FORMATION OF UTERINE RIBOSOMES.
Proc Natl Acad Sci U S A. 1964 Aug;52(2):439-46. doi: 10.1073/pnas.52.2.439.
Zotero 插件