Li G C, Hahn G M, Shiu E C
J Cell Physiol. 1977 Dec;93(3):331-4. doi: 10.1002/jcp.1040930303.
At 43 degrees C (but not at 41 degrees C), organic solvents used to dissolve water-insoluble chemotherapeutic agents become themselves lethal to cells. This finding is not unique to Chinese hamster cells (HA-1); mouse mammary sarcoma cells (EMT-6) behave similarly. The solvent concentrations involved are in the range of those needed to make drug solutions. Hence experiments measuring drug-cell interactions at elevated temperatures must include controls which independently measure solvent effects.
在43摄氏度（而非41摄氏度）时，用于溶解水不溶性化疗药物的有机溶剂本身会对细胞产生致命影响。这一发现并非中国仓鼠细胞（HA - 1）所特有；小鼠乳腺肉瘤细胞（EMT - 6）也有类似表现。所涉及的溶剂浓度处于配制药物溶液所需的范围内。因此，在高温下测量药物与细胞相互作用的实验必须包括独立测量溶剂效应的对照实验。
