乙硫氨酸对雄性和雌性大鼠肝脏粗面内质网的影响。
Effect of ethionine on the rough endoplasmic reticulum from male and female rat liver.
作者信息
Czosnek H H, Ascarelli A, De Groot N, Hergenhahn M, Hochberg A A
出版信息
Mol Biol Rep. 1977 Dec;3(6):459-66. doi: 10.1007/BF00808388.
Ethionine causes a decrease in the amount of rough endoplasmic reticulum in rat liver, the effect being greater in female than in male rats. Rough endoplasmic reticulum isolated from rat liver 24 hr after ethionine injection and stripped of its ribosomes partially lost its in vitro ribosome binding capacity. However, no differences were detected between the binding affinities of ribosomes, isolated from either untreated animals or intoxicated rats, to stripped rough membranes derived from normal rats. Structural changes occur in the rough endoplasmic reticulum of the ethionine treated rats, while the ribosomes are still bound to the membrane.
乙硫氨酸会导致大鼠肝脏中粗面内质网数量减少，雌性大鼠受到的影响比雄性大鼠更大。在注射乙硫氨酸24小时后从大鼠肝脏分离出的粗面内质网，去除核糖体后其体外核糖体结合能力部分丧失。然而，从未经处理的动物或中毒大鼠分离出的核糖体与从正常大鼠分离出的去除核糖体的粗面内质网膜的结合亲和力之间未检测到差异。在乙硫氨酸处理的大鼠的粗面内质网中会发生结构变化，而此时核糖体仍与膜结合。
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