Schlaeger M, Pullmann H, Gottmann-Lückerath I
Z Hautkr. 1977 Nov 15;52(22):1142-6.
Specific IgE-fractions can be determined in the blood serum by Radio-Allergo-Sorbent-Test (RAST). The positive tests are arranged into four groups, the so called RAST-classes, of which class 1 represents the lowest, class 4 the highest content of specific IgE. The diagnostical value of equal RAST-classes among the groups of allergens is different. We examined 13 600 allergens in 700 patients by RAST and found 2441 positive reactions. It turned out that especially in weeds, house dust and mould allergy, the lower RAST-classes are predominant with more than 90 per cent. In grass pollen allergy, a comparable percentage of positive tests accumulates in the range of RAST-class 3. From this distribution of positive tests we concluded, that in house dust, mould and weeds pollen allergy RAST-class 1 has a real diagnostical value and can be the basis of therapeutical consequences. In patients with lower RAST-classes in mould, house dust and weed pollen allergy, in our experience, the average total IgE is already in a pathological range; in patients with grass pollen allergy total IgE is increased pathologically almost until RAST-class 4.
通过放射变应原吸附试验（RAST）可测定血清中的特异性IgE组分。阳性试验结果分为四组，即所谓的RAST等级，其中1级表示特异性IgE含量最低，4级表示最高。不同变应原组中相同RAST等级的诊断价值有所不同。我们通过RAST对700名患者的13600种变应原进行了检测，发现2441例阳性反应。结果表明，尤其是在杂草、屋尘和霉菌过敏中，90%以上的阳性反应集中在较低的RAST等级。在草花粉过敏中，相当比例的阳性试验集中在RAST 3级范围内。根据阳性试验的这种分布情况，我们得出结论，在屋尘、霉菌和杂草花粉过敏中，RAST 1级具有实际诊断价值，可作为治疗决策的依据。根据我们的经验，在霉菌、屋尘和杂草花粉过敏中RAST等级较低的患者，其总IgE平均已处于病理范围；在草花粉过敏患者中，总IgE几乎在RAST 4级时才出现病理性升高。
