卵磷脂、磷脂酰乙醇胺和磷脂酸的新型部分可水解合成类似物。

New, partially hydrolyzable synthetic analogues of lecithin, phosphatidyl ethanolamine, and phosphatidic acid.

作者信息

Rosenthal A F

出版信息

J Lipid Res. 1966 Nov;7(6):779-85.

Abstract

The synthesis of two new synthetic analogues of lecithin, two of phosphatidyl ethanolamine ("cephalin"), and one new phosphatidic acid analogue is described. They comprise one of each of the following types: the "isosteric" diether lecithin and cephalin analogues ROCH(2)CH(OR)- CH(2)CH(2)P(O) (O(-))OCH(2)CH(2)N(+)R'(3) (R = C(18)H(37); R' = H or CH(3)); and the "hydrocarbon" analogues of phosphatidic acid, lecithin, and cephalin, C(17)H(35)CH(2)CH(C(18)H(37))CH(2)P(O)(R) = (R'); [R = R' = OH; R = O(-), R' = OCH(2)CH(2)N(+)(CH(3))(3); and R = O(-), R' = OCH(2)CH(2)N(+)H(3)]. Infrared spectra and other properties of these compounds are described.

摘要

本文描述了两种新的卵磷脂合成类似物、两种磷脂酰乙醇胺（“脑磷脂”）类似物以及一种新的磷脂酸类似物的合成。它们分别属于以下类型：“等排”二醚卵磷脂和脑磷脂类似物ROCH(2)CH(OR)- CH(2)CH(2)P(O) (O(-))OCH(2)CH(2)N(+)R'(3) （R = C(18)H(37)；R' = H或CH(3)）；以及磷脂酸、卵磷脂和脑磷脂的“烃类”类似物，C(17)H(35)CH(2)CH(C(18)H(37))CH(2)P(O)(R) = (R')；[R = R' = OH；R = O(-)，R' = OCH(2)CH(2)N(+)(CH(3))(3)；以及R = O(-)，R' = OCH(2)CH(2)N(+)H(3)]。文中还描述了这些化合物的红外光谱及其他性质。