Gravis C J
Cell Tissue Res. 1977 Dec 19;185(3):303-13. doi: 10.1007/BF00220291.
The testes of Syrian hamsters underwent pronounced involution within six weeks after blinding. The seminiferous tubules were devoid of all stages of spermatid development and mature spermatozoa were absent from the tubule lumina. The diameter of of the Leydig cells was 25% less than that of controls. Examination with the electron microscope revealed thick bundles of collagen fibrils interspersed between Leydig cells and surrounding Leydig cells in the blinded hamsters. The Leydig cell nuclei were shrunken and highly infolded. Lipid droplets that were often seen in normal Leydig cells were absent in the involuting Leydig cells. The size of the Golgi complex and the amount of smooth endoplasmic reticulum were reduced. Results of the present experiment confirm that inactivity of the Leydig cells is the reason for the decline in serum testosterone levels in blinded hamsters.
叙利亚仓鼠的睾丸在失明后六周内发生明显退化。生精小管中没有精子细胞发育的各个阶段，管腔中也没有成熟精子。睾丸间质细胞的直径比对照组小25%。电子显微镜检查发现，在失明仓鼠的睾丸间质细胞之间和周围散布着粗大的胶原纤维束。睾丸间质细胞核萎缩且高度折叠。退化的睾丸间质细胞中没有正常睾丸间质细胞中常见的脂滴。高尔基体的大小和平滑内质网的数量减少。本实验结果证实，睾丸间质细胞活性降低是失明仓鼠血清睾酮水平下降的原因。
