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小鼠流感病毒感染的实验性传播。IV. 不同病毒株的传播性与感染小鼠环境中空气传播病毒回收的关系。

Experimental transmission of influenza virus infection in mice. IV. Relationship of transmissibility of different strains of virus and recovery of airborne virus in the environment of infector mice.

作者信息

Schulman J L

出版信息

J Exp Med. 1967 Mar 1;125(3):479-88. doi: 10.1084/jem.125.3.479.

Abstract

A mouse-adapted Jap. 305 strain of influenza A(2) virus was found to be much more readily transmitted from one mouse to another than the NWS strain of influenza A(0) virus although the two viruses were equally pathogenic for mice as judged by pulmonary virus titers and lung lesions. The survival of artificially created aerosols of virus and the quantity of airborne virus required to initiate infection in mice were identical for the two viruses. The difference in transmissibility was associated with the recovery of infectious airborne virus in the environment of mice infected with the Jap. 305 strain during the period of their maximum infectiousness, but not in the environment of mice infected with the NWS strain.

摘要

一种适应小鼠的甲型(2)流感病毒日本305株,被发现比甲型(0)流感病毒NWS株更容易在小鼠之间传播,尽管根据肺部病毒滴度和肺部病变判断,这两种病毒对小鼠的致病性相同。两种病毒在人工产生的病毒气溶胶中的存活情况以及在小鼠中引发感染所需的空气传播病毒量是相同的。传播性的差异与感染日本305株的小鼠在其传染性最强时期环境中传染性空气传播病毒的回收有关,而感染NWS株的小鼠环境中则没有这种情况。

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