Goodger B V, Wright I G
Z Parasitenkd. 1977 Dec 13;54(1):9-27. doi: 10.1007/BF00380633.
The results of this paper indicate that cattle infected with B. bovis (argentina) have a markedly altered and activated coagulation system. A degree of thrombin activation occurs due partly to release of thromboplastin-like substances from lysed erythrocytes but due primarily to activation of kallikrein by babesial proteases. This produces a hyperfibrinogenaemia, particularly in intact cattle, with soluble fibrin complexes constituting up to one-third of the total fibrinogen concentration. High molecular weight non-coagulable fibrinogen-like proteins are detected terminally but more so in splenectomized cattle. Plasminogen concentration decreases in splenectomized but not intact cattle while low molecular weight fibrinogen degradation products are not easily detected. It is suggested that a hypercoagulable intermediate state with little or no fibrin deposition occurs rather than terminal disseminated intravascular coagulation.
本文结果表明，感染牛巴贝斯虫（阿根廷株）的牛凝血系统发生了显著改变并被激活。凝血酶的一定程度激活部分归因于裂解红细胞释放出类凝血活酶物质，但主要是由于巴贝斯虫蛋白酶激活激肽释放酶。这导致血纤维蛋白原血症，尤其是在未切除脾脏的牛中，可溶性纤维蛋白复合物占总纤维蛋白原浓度的三分之一。在病程末期可检测到高分子量不可凝的类纤维蛋白原蛋白，但在脾切除的牛中更明显。脾切除的牛中纤溶酶原浓度降低，而未切除脾脏的牛中则未降低，且不易检测到低分子量纤维蛋白原降解产物。有人提出，发生的是几乎没有或没有纤维蛋白沉积的高凝中间状态，而不是终末期弥散性血管内凝血。
