抗惊厥药物的致畸学评估。
A teratological evaluation of anticonvulsant drugs.
作者信息
Lakos P, Czeizel E
出版信息
Acta Paediatr Acad Sci Hung. 1977;18(2):145-53.
PMID:602761
Abstract
Reviewing the important teratological data on anticonvulsants, the Hungarian experiences are reported. In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida. The teratogenic effect of diphenyl-hydantoin was confirmed, while that of diazepam and phenobarbital was not supported.
摘要
回顾抗惊厥药的重要致畸学数据，报告了匈牙利的经验。在匈牙利先天性畸形登记处，确定了在妊娠期间使用抗惊厥药地西泮和苯巴比妥的情况，这些药物用于患有唇裂（伴或不伴腭裂）、后腭裂的婴儿，以及作为对照的无脑儿和脊柱裂婴儿。苯妥英的致畸作用得到了证实，而地西泮和苯巴比妥的致畸作用未得到支持。
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引用本文的文献
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Cleft lip with or without cleft palate: identification of sporadic cases with a high level of genetic predisposition.唇裂伴或不伴腭裂：具有高度遗传易感性的散发病例的识别。
J Med Genet. 1987 Mar;24(3):163-9. doi: 10.1136/jmg.24.3.163.
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