可乐定对基础及冷刺激促甲状腺激素分泌的影响。
Effects of clonidine on basal and cold-stimulated TSH secretion.
作者信息
Scapagnini U, Annunziato L, Di Renzo G F, Schettini G, Preziosi P
出版信息
Arch Int Pharmacodyn Ther. 1977 Dec;230(2):220-4.
Clonidine, injected i.p. 20 min before cold exposure, is able to counteract the blockade induced by alpha-methyl-p-tyrosine of cold-stimulated release of TSH in rats. Under basal conditions the alpha-adrenoceptor stimulating agent, administered into the lateral cerebral ventricle (10 microgram), produces, at 30 min, a sharp increase in plasma TSH that returns to control levels at 60 min. When the drug is given intraperitoneally (0.4 mg/kg) it causes a significant decrease in plasma TSH 120 min after the treatment.
可乐定在冷暴露前20分钟腹腔注射，能够对抗α-甲基对酪氨酸诱导的大鼠冷刺激促甲状腺激素释放的阻断作用。在基础条件下，将α-肾上腺素能受体刺激剂注入侧脑室（10微克），30分钟时血浆促甲状腺激素急剧增加，60分钟时恢复到对照水平。当该药物腹腔注射（0.4毫克/千克）时，给药后120分钟血浆促甲状腺激素显著降低。
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