Megahed G E, Senna G A, Eissa M H, Saleh S Z, Eissa H A
Thorax. 1967 May;22(3):271-8. doi: 10.1136/thx.22.3.271.
The smoking habits of 50 proved cases of chronic bronchitis were studied. Bronchoscopy was done and a bronchial biopsy was taken for histological examination. Bronchial lavage was obtained under sterile conditions for bacteriological studies. The degree of bronchial mucous gland hypertrophy was determined, and the presence or absence of infection, as shown by the presence of potential pathogens in the bronchial lavage, was noted. We think that tobacco smoking and its resulting irritation to the bronchi is the most important underlying cause of bronchial mucous gland hypertrophy because there is: (1) a significantly higher incidence of mucous gland hypertrophy in smokers than in non-smokers among the 50 chronic bronchitics studied; (2) a significantly higher accumulated lifetime tobacco consumption in patients exhibiting mucous gland hypertrophy than in those without hypertrophy of the bronchial mucous glands; (3) a significant association and correlation between the degree of mucous gland hypertrophy and the intensity of smoking; and (4) no difference in the comparative frequency of occurrence of bronchial mucous gland hypertrophy in subjects with and without demonstrable infection, as shown by the presence of potential pathogens in the bronchial lavage. We could not deny that infection might be having an initiating or potentiating effect.
对50例确诊的慢性支气管炎患者的吸烟习惯进行了研究。进行了支气管镜检查，并取支气管活检进行组织学检查。在无菌条件下获取支气管灌洗样本用于细菌学研究。测定支气管黏液腺肥大的程度，并记录支气管灌洗中是否存在潜在病原体所显示的感染情况。我们认为吸烟及其对支气管产生的刺激是支气管黏液腺肥大最重要的潜在原因，因为：（1）在研究的50例慢性支气管炎患者中，吸烟者黏液腺肥大的发生率显著高于非吸烟者；（2）出现黏液腺肥大的患者累积终生烟草消费量显著高于未出现支气管黏液腺肥大的患者；（3）黏液腺肥大程度与吸烟强度之间存在显著关联和相关性；（4）支气管灌洗中存在潜在病原体所显示的，有或无明显感染的受试者中支气管黏液腺肥大的相对发生频率没有差异。我们不能否认感染可能具有引发或增强作用。
