急性氯化物缺乏大鼠的利钠作用

Natriuresis in rats acutely depleted of chloride.

Luke R G, Khanh B T, Schmidt R D, Galla J H

Clin Sci Mol Med. 1977 Jan;52(1):23-31. doi: 10.1042/cs0520023.

Abstract

Acute chloride depletion, without sodium depletion, was produced in rats by a single exchange peritoneal dialysis against sodium bicarbonate solution. Blood volume was restored after dialysis by infusion of salt-free albumin, and exogenous deoxycorticosterone and antidiuretic hormone were given. 2. Clearance studies in the period (3 h) after dialysis revealed no difference in the glomerular filtration rate or in the filtered sodium load between experimental and control rats but urinary sodium concentrations and absolute and fractional sodium excretion were significantly higher in the chloride-depleted group. 3. There was also a significant kaliuresis, increased urinary flow rate and diminished free water reabsorption. Urinary bicarbonate excretion increased to a variable degree but the major rise in anion excretion was 'unmeasured' (Na+ + K+ - [Cl- + HCO3- + PO4(3-)]). 4. It is postulated that chloride depletion imposes limitations on sodium reabsorption in the ascending limb of the loop of Henle.

摘要

通过用碳酸氢钠溶液进行单次交换腹膜透析，在大鼠中造成无钠缺乏的急性氯缺乏。透析后通过输注无盐白蛋白恢复血容量，并给予外源性脱氧皮质酮和抗利尿激素。2. 透析后（3小时）的清除率研究表明，实验大鼠和对照大鼠之间的肾小球滤过率或滤过钠负荷没有差异，但氯缺乏组的尿钠浓度、绝对和分数钠排泄显著更高。3. 也有显著的尿钾增多、尿流率增加和自由水重吸收减少。尿碳酸氢盐排泄有不同程度增加，但阴离子排泄的主要增加是“未测定的”（Na⁺ + K⁺ - [Cl⁻ + HCO₃⁻ + PO₄³⁻]）。4. 据推测，氯缺乏对髓袢升支粗段的钠重吸收施加了限制。