一种用于研究蛋白质结合对离体灌注大鼠肾脏制剂中药物肾脏处理影响的简单系统。
A simple system for the investigation of protein binding effects on the renal handling of drugs in an isolated perfused rat kidney preparation.
作者信息
Hall S D, Rowland M
出版信息
J Pharmacol Methods. 1984 Sep;12(2):85-9. doi: 10.1016/0160-5402(84)90025-1.
PMID:6085642
Abstract
An isolated perfused rat kidney preparation was developed that allowed drug-protein binding in the perfusate to be varied while maintaining renal function. When applied to digitoxin and frusemide, two drugs highly bound to bovine serum albumin, the fraction of drug unbound could be continuously varied over approximately a 30-fold range.
摘要
已开发出一种分离灌注大鼠肾脏的制备方法，该方法可在维持肾功能的同时改变灌注液中药物与蛋白质的结合情况。当应用于地高辛和速尿这两种与牛血清白蛋白高度结合的药物时，未结合药物的比例可在约30倍的范围内连续变化。
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