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[周围软组织肉瘤。对90例初次治疗患者的回顾性研究]

[Peripheral soft tissue sarcomas. A retrospective study on 90 primary treatment patients].

作者信息

Ries G, Lindner H, Hötzinger H, Atzinger A, Pfändner K

出版信息

Strahlentherapie. 1984 Jun;160(6):357-62.

PMID:6087499
Abstract

Between 1960 and 1982, 90 patients treated primarily for peripheral soft tissue sarcomas received a postoperative irradiation at the Irradiation Department of the Städtische Krankenhaus Passau. Five patients (6%) were inoperable for internistic reasons and were treated only by radiotherapy. The local recurrence rate after combined therapy was 26%. 44% of the patients (40/90) developed metastases, preponderantly in the lung and within the first year (70% each). The age-corrected survival rate was 63% after five years and 43% after ten years in 79 patients with complete postoperative irradiation. Important prognostic factors are the degree of malignancy (five-year survival times of 57 patients: almost 90% for G1 tumors, 50% for G2 tumors, and 17% for G3 tumors, statistically significant) as well as the completeness of surgery. It is shown by the available results that conservative surgical interventions combined with radiotherapy are not less effective than more radical operations.

摘要

1960年至1982年间,90例主要因外周软组织肉瘤接受治疗的患者在帕绍市立医院放疗科接受了术后放疗。5例患者(6%)因内科原因无法手术,仅接受了放疗。联合治疗后的局部复发率为26%。44%的患者(40/90)发生了转移,主要转移至肺部,且多在第一年发生(各占70%)。79例术后接受完整放疗的患者,其年龄校正后的五年生存率为63%,十年生存率为43%。重要的预后因素包括恶性程度(57例患者的五年生存时间:G1肿瘤近90%,G2肿瘤50%,G3肿瘤17%,具有统计学意义)以及手术的完整性。现有结果表明,保守性手术干预联合放疗并不比更激进的手术效果差。

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