Hill A B, May W, Kaminsky L S, Levy J A, Penny R, Cooper D A
Med J Aust. 1984 Oct 27;141(9):573-8.
Fifty-six patients were referred in 1983 for assessment in connection with AIDS and related disorders. Clinical and immunological classification of patients was carried out according to the NHMRC criteria. The presence of antibodies to an AIDS-associated retrovirus (ARV) was determined in some patients. Of the 32 patients who could be categorized, three patients had AIDS, and all three had serum antibodies to ARV. Fifteen patients had lymphadenopathy syndrome with impaired T-cell immunity. Ten of 12 patients tested had antibodies to ARV. Symptomatic illnesses resembling lymphadenopathy syndrome, but without immune defects, occurred in nine patients. By contrast, five patients who had no symptoms had impaired immunity, and in seven patients no clinical and immunological abnormalities were found. The classification proposed by the NHMRC was found to be useful in delineating several major clinical and immunological patterns of response to infection with the AIDS-associated retrovirus.
1983年,有56名患者因艾滋病及相关疾病前来接受评估。根据澳大利亚国家卫生与医学研究委员会(NHMRC)的标准对患者进行了临床和免疫学分类。部分患者检测了艾滋病相关逆转录病毒(ARV)抗体。在可分类的32名患者中,3名患有艾滋病,且这3名患者均有ARV血清抗体。15名患者患有淋巴结病综合征且T细胞免疫功能受损。在接受检测的12名患者中,10名有ARV抗体。9名患者出现了类似淋巴结病综合征的症状性疾病,但无免疫缺陷。相比之下,5名无症状患者存在免疫功能受损,7名患者未发现临床和免疫学异常。发现NHMRC提出的分类有助于描绘对艾滋病相关逆转录病毒感染的几种主要临床和免疫反应模式。