Kavaliers M, Podesta R B, Hirst M, Young B
Life Sci. 1984 Dec 3;35(23):2365-73. doi: 10.1016/0024-3205(84)90529-0.
Nociceptive thresholds were investigated in golden hamsters infected with the human blood fluke, Schistosoma mansoni. Increases in thermal thresholds suggestive of analgesia were evident by 20-25 days of infection. These increased further during a 40-42 day period. The altered responses were suppressed by the opioid antagonist naloxone. Non-invasive inhibition of the activity of the pineal gland by exposure to light also reduced nocturnal analgesia in schistosome infected animals. Naloxone antagonism and pineal inhibition of morphine- induced analgesia was obtained similarly in control, uninfected animals. Taken together, these findings suggest strongly that infection with S. mansoni results in a chronic activation of the endogenous opiate system.
对感染人血吸虫曼氏血吸虫的金黄仓鼠的痛觉阈值进行了研究。感染20 - 25天时，热阈值升高提示镇痛作用明显。在40 - 42天期间，这些阈值进一步升高。阿片类拮抗剂纳洛酮可抑制这些改变的反应。暴露于光线下对松果体活动的非侵入性抑制也降低了血吸虫感染动物的夜间镇痛作用。在未感染的对照动物中，纳洛酮拮抗作用和松果体对吗啡诱导镇痛的抑制作用也类似。综上所述，这些发现强烈表明，曼氏血吸虫感染会导致内源性阿片系统的慢性激活。
