25年后的吉南四胞胎：诊断与生化随访

The Genain Quadruplets 25 years later: a diagnostic and biochemical followup.

作者信息

DeLisi L E, Mirsky A F, Buchsbaum M S, van Kammen D P, Berman K F, Caton C, Kafka M S, Ninan P T, Phelps B H, Karoum F

出版信息

Psychiatry Res. 1984 Sep;13(1):59-76. doi: 10.1016/0165-1781(84)90119-7.

Abstract

A biological and clinical followup of the Genain Quadruplets was initiated as a multilaboratory collaborative effort at the National Institute of Mental Health (NIMH). The quadruplets are 51-year-old monozygotic women previously studied with a battery of psychological and physiological tests 25 years ago at the NIMH. The present article (the first of a series of three) details the clinical history and course of the schizophrenic illness in each of the quadruplets and describes the biochemical measures determined. The findings of elevated urinary phenylethylamine excretion, decreased plasma dopamine-beta-hydroxylase activity, and increased alpha-adrenergic receptor concentrations in all quadruplets warrant further genetic studies.

摘要

作为美国国立精神卫生研究所（NIMH）的一项多实验室合作项目，对吉奈四胞胎进行了生物学和临床随访。这四胞胎是51岁的同卵女性，25年前曾在美国国立精神卫生研究所接受了一系列心理和生理测试。本文（系列文章共三篇中的第一篇）详细介绍了每个四胞胎的精神分裂症临床病史和病程，并描述了所测定的生化指标。所有四胞胎尿中苯乙胺排泄量升高、血浆多巴胺-β-羟化酶活性降低以及α-肾上腺素能受体浓度增加的结果值得进一步开展遗传学研究。