Nadelhaft I
Biophys J. 1976 Oct;16(10):1125-30. doi: 10.1016/S0006-3495(76)85762-1.
A phenomenological model of the process of fast axoplasmic transport is presented. The process was conceived of as occurring in two parts: (a) synthesis and storage of material in a cytoplasmic pool; (b) release from the pool and transport distally along the axon. Considering the fate of labeled proteins, the activity at points along the axon relfects events occurring earlier within the pool through the relationship: g(x,t) = const f(t - x/v); where g(x,t) represents axonal activity, f(t) the pool's activity, and v is the transport speed. Using the idea that when there is no further input of radioactivity into the pool its activity declines exponentially due to export of material to the axon. I generalized this concept to the case where activity enters and leaves the pool simultaneously. The model contains two parameters: the relative turnover rate of the pool, alpha, and T, an interval characteristic of the time of synthesis. From this model, the experimental data is unfolded and yields values for these parameters of alpha = 0.004 min-1 and T approximately 60 min.
本文提出了快速轴浆运输过程的现象学模型。该过程被认为分两个部分发生：（a）物质在细胞质池中的合成与储存；（b）从池中释放并沿轴突向远端运输。考虑标记蛋白质的命运，轴突上各点的活性通过以下关系反映池中早期发生的事件：g(x,t) = const f(t - x/v)；其中g(x,t)表示轴突活性，f(t)表示池的活性，v是运输速度。基于当池中不再有放射性物质输入时，其活性由于物质向轴突输出而呈指数下降这一观点，我将这一概念推广到活性同时进入和离开池的情况。该模型包含两个参数：池的相对周转率α和T，合成时间的一个特征间隔。从这个模型中，可以解读实验数据，并得出这些参数的值，α = 0.004 min⁻¹，T约为60分钟。
