用腺苷脱氨酶抑制剂2'-脱氧助间型霉素诱导甲状腺淋巴细胞白血病缓解

Remission induction with adenosine-deaminase inhibitor 2'-deoxycoformycin in Thy-lymphoblastic leukaemia.

作者信息

Prentice H G, Smyth J F, Ganeshaguru K, Wonke B, Bradstock K F, Janossy G, Goldstone A H, Hoffbrand A V

出版信息

Lancet. 1980 Jul 26;2(8187):170-2. doi: 10.1016/s0140-6736(80)90060-4.

Abstract

Two patients with relapsed acute lymphoblastic leukaemia of thymic phenotype (Thy-ALL) resistant to all conventional chemotherapy achieved complete remission when treated with 2'-deoxycoformycin, a selectively lymphocytotoxic compound that acts by inhibition of the enzyme adenosine deaminase. These observations show that malignant thymocytes are dependent on adenosine-deaminase activity and suggest that it may be possible to use deoxycoformycin in other patients with Thy-ALL to induce remission or to kill Thy-ALL blasts in bone marrow harvested before autologous bone-marrow transplantation, leaving normal haemopoietic stem cells intact.

摘要

两名胸腺表型复发急性淋巴细胞白血病（Thy-ALL）患者对所有常规化疗均耐药，在接受2'-脱氧助间型霉素治疗后实现完全缓解。2'-脱氧助间型霉素是一种选择性淋巴细胞毒性化合物，通过抑制腺苷脱氨酶发挥作用。这些观察结果表明，恶性胸腺细胞依赖腺苷脱氨酶活性，并提示对于其他Thy-ALL患者，有可能使用脱氧助间型霉素诱导缓解，或在自体骨髓移植前采集的骨髓中杀死Thy-ALL原始细胞，同时保持正常造血干细胞完好无损。