Pearson D, Shively J E, Clark B R, Geschwind I I, Barkley M, Nishioka R S, Bern H A
Proc Natl Acad Sci U S A. 1980 Aug;77(8):5021-4. doi: 10.1073/pnas.77.8.5021.
Urotensin II, a peptide hormone from the caudal neurosecretory system of the teleost, Gillichthys mirabilis, was isolated by using classical chromatographic techniques and high-performance liquid chromatography (HPLC). Direct microtechniques for sequence determination were used to establish its structure. Urotensin II from Gillichthys is a 1363-dalton dodecapeptide with the amino acid sequence Ala-Gly-Thr-Ala-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val. This sequence is homologous with somatostatin in positions 1 and 2 and 7-9. The sequence has been verified by the production of a bioactive synthetic urotensin II. The possible chemical and physiological significance of its homology to somatostatin is discussed.
尿紧张素II是一种来自硬骨鱼奇异银汉鱼尾部神经分泌系统的肽类激素，通过经典色谱技术和高效液相色谱（HPLC）进行分离。采用直接微量技术进行序列测定以确定其结构。奇异银汉鱼的尿紧张素II是一种1363道尔顿的十二肽，氨基酸序列为丙氨酸-甘氨酸-苏氨酸-丙氨酸-天冬氨酸-半胱氨酸-苯丙氨酸-色氨酸-赖氨酸-酪氨酸-半胱氨酸-缬氨酸。该序列在第1、2位以及第7至9位与生长抑素具有同源性。通过合成具有生物活性的尿紧张素II验证了该序列。文中讨论了其与生长抑素同源性可能的化学和生理意义。
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