人类胶质肿瘤中的过氧化物酶体（微体）：细胞化学超微结构研究

Peroxisomes (microbodies) in human glial tumors. a cytochemical ultrastructural study.

作者信息

Sima A A

出版信息

Acta Neuropathol. 1980;51(2):113-7. doi: 10.1007/BF00690452.

Abstract

Morphologically and cytochemically defined peroxisomes (microbodies) were demonstrated in a series of 11 human glial tumors. The cytochemical methods used were diaminobenzidine method for catalase and a tetrazolium salt-phenozine methosulfate method for D-amino-acid oxidase. Ultrastructurally, the peroxisomes were found as single membrane limited organelles with a granular matrix. Marginal plates as well as continuities with the smooth endoplasmic reticulum could be demonstrated. Peroxisomes were found most abundantly in subependymal giant cell astrocytomas, to a lesser number in astrocytomas and least abundantly in glioblastomas.

摘要

在一系列11例人类神经胶质瘤中，通过形态学和细胞化学方法证实了过氧化物酶体（微体）的存在。所使用的细胞化学方法包括用于过氧化氢酶的二氨基联苯胺法和用于D-氨基酸氧化酶的四氮唑盐-吩嗪硫酸甲酯法。在超微结构上，过氧化物酶体是具有颗粒状基质的单膜限制细胞器。可以证明其边缘板以及与滑面内质网的连续性。过氧化物酶体在室管膜下巨细胞星形细胞瘤中含量最多，在星形细胞瘤中数量较少，在胶质母细胞瘤中含量最少。