支气管刺激感受器在哮喘中的作用。

Role of bronchial irritant receptors in asthma.

作者信息

Harries M G, Parkes P E, Lessof M H, Orr T S

出版信息

Lancet. 1981 Jan 3;1(8210):5-7. doi: 10.1016/s0140-6736(81)90113-6.

Abstract

Sulphur dioxide inhaled at low concentration had no detectable effect on forced expiratory volume in one second in non-asthmatic atopic controls, but it induced asthma and increased bronchial reactivity in nine symptomless atopic and non-atopic asthmatic patients. This increased reactivity was inhibited by sodium cromoglycate (SCG) and partly inhibited by atropine. This suggests that SCG, in addition to its ability to stabilise mast cells, may also act on bronchial irritant receptors or directly on smooth muscle in asthmatic patients.

摘要

低浓度吸入二氧化硫对非哮喘性特应性对照者的一秒用力呼气量没有可检测到的影响，但它诱发了9名无症状特应性和非特应性哮喘患者的哮喘并增加了支气管反应性。这种增加的反应性被色甘酸钠（SCG）抑制，并被阿托品部分抑制。这表明，SCG除了具有稳定肥大细胞的能力外，还可能作用于哮喘患者的支气管刺激感受器或直接作用于平滑肌。