生长抑素对人体中蛙皮素刺激的血清胃泌素及胃酸分泌的影响。

The effect of somatostatin on bombesin-stimulated serum gastrin and gastric acid secretion in man.

作者信息

Jansen J B, Lamers C B

出版信息

Digestion. 1981;21(4):193-7. doi: 10.1159/000198562.

DOI:10.1159/000198562

Abstract

The effect of intravenous somatostatin on bombesin-stimulated serum gastrin and gastric acid secretion was studied in 5 healthy subjects. Somatostatin, 100 ng/kg/min, significantly inhibited serum gastrin and gastric acid responses to infusion of bombesin-tetradecapeptide in a dose of 2.5 ng/kg/min. Inhibition of gastrin release could not fully account for the inhibition of gastric acid secretion. Since both bombesin and somatostatin are present in the antrum of man, interrelations between these peptides might be involved in gastrin release from the antrum.

摘要

在5名健康受试者中研究了静脉注射生长抑素对蛙皮素刺激的血清胃泌素及胃酸分泌的影响。以100 ng/kg/min的速度静脉注射生长抑素，可显著抑制静脉注射剂量为2.5 ng/kg/min的蛙皮素-十四肽所引起的血清胃泌素及胃酸反应。胃泌素释放的抑制并不能完全解释胃酸分泌的抑制。由于蛙皮素和生长抑素在人的胃窦中均有存在，这些肽之间的相互关系可能参与胃窦中胃泌素的释放。