法扎氯铵对琥珀酰胆碱引起的钾外流的影响。

The influence of fazadinium on the potassium efflux produced by succinylcholine.

作者信息

Famewo C E

出版信息

Can Anaesth Soc J. 1981 Sep;28(5):463-6. doi: 10.1007/BF03010357.

Abstract

Succinylcholine-induced potassium efflux was studied in two groups of healthy adult patients presenting for elective surgery. One group (Group 1) of 12 patients received alfathesin induction followed by succinylcholine. The other group (Group 2) of 12 patients were pre-treated with fazadinium 0.075 mg . kg-1 about three minutes before administration of alfathesin and succinylcholine. Serial blood samples were taken pre-induction, post-induction and after succinylcholine for estimation of plasma potassium. The results show that pre-treatment with fazadinium 0.075 mg . kg-1 was effective in preventing succinylcholine-induced potassium efflux.

摘要

在两组择期手术的健康成年患者中研究了琥珀酰胆碱诱导的钾外流。一组（第1组）12例患者接受阿法沙辛诱导诱导，随后给予琥珀酰胆碱。另一组（第2组）12例患者在给予阿法沙辛和琥珀酰胆碱前约三分钟，先用0.075mg·kg-1的法扎溴铵预处理。在诱导前、诱导后和给予琥珀酰胆碱后采集系列血样，以评估血浆钾。结果表明，0.075mg·kg-1的法扎溴铵预处理可有效预防琥珀酰胆碱诱导的钾外流。