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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Caffier G, Pfeiffer C

Acta Biol Med Ger. 1977;36(7-8):1077-84.

Nonanoic acid causes a depression in the contractile force of rat papillary muscles working isometrically. The effect depends on both the concentration of the fatty acid (0.1-1 mM) and the time of exposure (2-12 min), and shows a nearly complete reversibility. 2. Vmax-values derived from the force-velocity relation as well as the index of relation suggested by Meerson do not change in muscles exposed to nonanoic acid. During paired pulse stimulation with a 400 ms-delay of the second impulse, both the postextrasystolic potentiation and the time to reach a new steady level in the contraction amplitude are significantly increased. The speed of restituting the contraction after a twitch (resitution) is descreased. 4. The results suggest that the action site of nonanoic acid may be the excitation-contraction coupling system (including the action potential) rather than the contractile element or the relaxation of the muscle.

壬酸会使等长收缩的大鼠乳头肌收缩力降低。该效应取决于脂肪酸的浓度（0.1 - 1 mM）和暴露时间（2 - 12分钟），并且几乎完全可逆。2. 从力 - 速度关系得出的Vmax值以及Meerson提出的关系指数在暴露于壬酸的肌肉中没有变化。在第二个冲动延迟400毫秒的成对脉冲刺激期间，期外收缩后增强以及收缩幅度达到新稳定水平的时间均显著增加。一次抽搐后恢复收缩的速度（恢复）降低。4. 结果表明，壬酸的作用部位可能是兴奋 - 收缩偶联系统（包括动作电位），而不是收缩元件或肌肉的舒张。

Caffier G, Pfeiffer C

Acta Biol Med Ger. 1977;36(7-8):1077-84.

Nonanoic acid causes a depression in the contractile force of rat papillary muscles working isometrically. The effect depends on both the concentration of the fatty acid (0.1-1 mM) and the time of exposure (2-12 min), and shows a nearly complete reversibility. 2. Vmax-values derived from the force-velocity relation as well as the index of relation suggested by Meerson do not change in muscles exposed to nonanoic acid. During paired pulse stimulation with a 400 ms-delay of the second impulse, both the postextrasystolic potentiation and the time to reach a new steady level in the contraction amplitude are significantly increased. The speed of restituting the contraction after a twitch (resitution) is descreased. 4. The results suggest that the action site of nonanoic acid may be the excitation-contraction coupling system (including the action potential) rather than the contractile element or the relaxation of the muscle.

壬酸会使等长收缩的大鼠乳头肌收缩力降低。该效应取决于脂肪酸的浓度（0.1 - 1 mM）和暴露时间（2 - 12分钟），并且几乎完全可逆。2. 从力 - 速度关系得出的Vmax值以及Meerson提出的关系指数在暴露于壬酸的肌肉中没有变化。在第二个冲动延迟400毫秒的成对脉冲刺激期间，期外收缩后增强以及收缩幅度达到新稳定水平的时间均显著增加。一次抽搐后恢复收缩的速度（恢复）降低。4. 结果表明，壬酸的作用部位可能是兴奋 - 收缩偶联系统（包括动作电位），而不是收缩元件或肌肉的舒张。