Changes in parasympathetic and sympathetic neurochemical indices in hearts of myopathic hamsters.

Sympathetic neurochemical indices in heart are increased in Syrian golden hamsters with skeletal and cardiac myopathy. The possibility that parasympathetic neurochemical indices might be altered was investigated in myopathic and normal hearts by measuring activity of choline acetyltransferase involved in acetylcholine synthesis. Confirming a previous report, tyrosine hydroxylase activity increased in failing myopathic hearts and norepinephrine concentration decreased. Extending previous work, tyrosine hydroxylase and dopamine-beta-hydroxylase activities in myopathic hearts demonstrated progressive, age-related increases. These changes were associated with reduced choline acetyltransferase activity in hearts of older myopathic hamsters (180 to 300-plus days). Decreases tended to be more pronounced in hamsters with cardiac hypertrophy and fluid retention (290-360 days old). Neurochemical evidence of increased sympathetic indices (dopamine-beta-hydroxylase activity) was detected at 30 days of age. Evidence of decreased parasympathetic indices (choline acetyltransferase activity) was detected at 180 days of age and persisted through terminal phases of heart failure. This study demonstrated that there are abnormalities in cardiac parasympathetic as well as cardiac sympathetic indices in myopathic hamsters.