Rottanburg D, Robins A H, Ben-Arie O, Teggin A, Elk R
Lancet. 1982 Dec 18;2(8312):1364-6. doi: 10.1016/s0140-6736(82)91270-3.
The mental state of 20 psychotic men with high urinary cannabinoid levels on admission to a psychiatric hospital was compared with that of 20 matched cannabis-free controls. All patients underwent toxicological analysis to exclude the presence of alcohol and other exogenous agents. Cannabis levels were measured by a semiquantitative enzyme immunological technique and mental state was assessed by the use of the Present State Examination (PSE), once shortly after admission and again 7 days later. The cannabis group showed significantly more hypomania and agitation and significantly less affective flattening, auditory hallucinations, incoherence of speech, and hysteria than did the controls. Clouding of consciousness was absent in most cannabis patients. After 1 week the cannabis group showed marked improvement (particularly in the psychotic syndromes), whereas the controls remained virtually unchanged. There was no significant difference in amount of medication received between the two groups. Our data suggest that a high intake of cannabis may be related to a rapidly resolving psychosis manifesting with marked hypomanic features, though often presenting as a schizophrenia-like illness.
对20名入住精神病院时尿液中大麻素水平较高的精神病男性患者的精神状态，与20名匹配的无大麻使用史的对照者进行了比较。所有患者均接受了毒理学分析，以排除酒精和其他外源性物质的存在。采用半定量酶免疫技术测量大麻水平，并使用现况检查（PSE）评估精神状态，入院后不久评估一次，7天后再次评估。与对照组相比，大麻组表现出明显更多的轻躁狂和激越，而情感平淡、幻听、言语不连贯和癔症则明显更少。大多数大麻患者不存在意识模糊。1周后，大麻组显示出明显改善（尤其是在精神病综合征方面），而对照组几乎没有变化。两组接受的药物剂量没有显著差异。我们的数据表明，大量摄入大麻可能与一种迅速缓解的精神病有关，这种精神病表现为明显的轻躁狂特征，尽管通常表现为类似精神分裂症的疾病。
