von Eyben F E, Skude G, Krabbe S
J Urol. 1982 Dec;128(6):1195-7. doi: 10.1016/s0022-5347(17)53420-5.
Serum lactate dehydrogenase and lactate dehydrogenase isoenzymes were determined as a screen for testicular germ cell neoplasia in 130 men with maldescended testes. A testicular tumor was found on clinical examination in 1 patient, which was revealed to be embryonal carcinoma, teratoma, yolk sac tumor and carcinoma in situ on orchiectomy. Subclinical testicular germ cell neoplasia was found on testicular biopsy in 3 men (1 with microinvasive seminoma and 2 with carcinoma in situ). These 4 patients had normal serum lactate dehydrogenase and serum lactate dehydrogenase isoenzymes. Elevated serum lactate dehydrogenase was noted in 3 men without testicular germ cell neoplasia: 1 had predominantly increased serum lactate dehydrogenase isoenzymes 1 to 3 and 2 had slightly increased serum lactate dehydrogenase isoenzymes 3 and 4. Serum lactate dehydrogenase and lactate dehydrogenase isoenzymes were not sensitive to detect testicular germ cell tumors in a subclinical stage.
对130例隐睾男性患者测定血清乳酸脱氢酶及其同工酶，以筛查睾丸生殖细胞肿瘤。临床检查发现1例患者有睾丸肿瘤，睾丸切除术后病理显示为胚胎癌、畸胎瘤、卵黄囊瘤及原位癌。睾丸活检发现3例男性有亚临床睾丸生殖细胞肿瘤（1例为微浸润性精原细胞瘤，2例为原位癌）。这4例患者的血清乳酸脱氢酶及其同工酶均正常。3例无睾丸生殖细胞肿瘤的男性血清乳酸脱氢酶升高：1例主要是血清乳酸脱氢酶同工酶1至3升高，2例血清乳酸脱氢酶同工酶3和4略有升高。血清乳酸脱氢酶及其同工酶对检测亚临床期睾丸生殖细胞肿瘤不敏感。
