大鼠再生肝脏中的过氧化物酶体酶活性。

Peroxisomal enzyme activities in regenerating liver of rats.

作者信息

Locci-Cubeddu T, Bergamini E

出版信息

Res Exp Med (Berl). 1982;181(3):225-30. doi: 10.1007/BF01851194.

Abstract

The activities of five peroxisomal enzymes (fatty acyl-CoA oxidase, FAO; uricase, U; L-hydroxyacid oxidase, LHAO; D-aminoacid oxidase, DAO; and catalase, C and the triglyceride content were determined in the regenerating liver of rats after partial hepatectomy. The FAO activity was significantly increased on day 3. Thus, its rise followed the increase of the triglyceride content and preceded the disappearance of steatosis. For U and LHAO a similar progressive increase in activities was obtained on days 3, 5, and 7 of regeneration. DAO exhibited a highly significant increase on day 1. C increased on day 1 and then again after day 3. It is concluded that peroxisomal functions are not restored at parallel rates during liver regeneration.

摘要

在部分肝切除术后大鼠再生肝中测定了五种过氧化物酶体酶（脂肪酰辅酶A氧化酶，FAO；尿酸酶，U；L-羟基酸氧化酶，LHAO；D-氨基酸氧化酶，DAO；以及过氧化氢酶，C）的活性和甘油三酯含量。FAO活性在第3天显著增加。因此，其升高跟随甘油三酯含量的增加并先于脂肪变性的消失。对于U和LHAO，在再生的第3、5和7天观察到活性有类似的逐渐增加。DAO在第1天表现出高度显著的增加。C在第1天增加，然后在第3天后再次增加。得出的结论是，在肝脏再生过程中过氧化物酶体功能并非以平行的速率恢复。