Orfila J
Bull Eur Physiopathol Respir. 1983 Mar-Apr;19(2):81-7.
Phagocytosis is a host's front line of cellular defence against bacteria. Some anatomical structures of the bacterial envelope may hinder this cellular activity. Amongst the most important constituents of the cell envelope, the capsule plays a very important role, its biochemical components being polysaccharide (pneumococcus, meningococcus), M proteins (streptococcus, yersinia, E. coli), mucopeptide (staphylococcus) or hyaluronic acid (streptococcus, Treponema pallidum). Complement plays an outstanding role by increasing the phagocytosis index. The studies of the different factors of the complement show that the degree of phagocytosis is correlated with the amount of C3 fixed on the surface of the bacteria. We still do not know the exact nature of the cell receptors, but the surface properties of the host cell and of the bacteria determine the contact angle which is of importance in this process.
吞噬作用是宿主针对细菌的细胞防御的第一道防线。细菌包膜的一些解剖结构可能会阻碍这种细胞活动。在细胞膜的最重要组成成分中,荚膜起着非常重要的作用,其生化成分包括多糖(肺炎球菌、脑膜炎球菌)、M蛋白(链球菌、耶尔森菌、大肠杆菌)、粘肽(葡萄球菌)或透明质酸(链球菌、梅毒螺旋体)。补体通过提高吞噬指数发挥着突出作用。对补体不同因子的研究表明,吞噬程度与固定在细菌表面的C3量相关。我们仍然不知道细胞受体的确切性质,但宿主细胞和细菌的表面特性决定了在此过程中至关重要的接触角。