由红藻氨酸诱导的青蛙脊髓中GABA受体的超敏反应。

Supersensitivity of the GABA receptor in the frog spinal cord, as induced by kainic acid.

作者信息

Ono H, Akahane K, Fukuda H, Kudo Y

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;76(2):231-6. doi: 10.1016/0742-8413(83)90070-1.

Abstract

In the isolated frog spinal cord perfused with kainic acid (KA, 5 X 10(-4) M) containing Ringer's solution, within 2 hr there were increases in the amplitude of the dorsal root depolarization, as induced by the GABA-agonists. KA perfusion produced increases in the specific binding of [3H]muscimol to crude synaptic membranes and incubation with KA for 3 hr did not increase [3H]muscimol binding. [3H]GABA was released from KA-treated spinal cord slices in the presence of high K+. KA-induced supersensitivity of the dorsal root to GABA may relate to direct actions on primary afferent terminals and not to denervation of GABAergic neurons.

摘要

在灌注含红藻氨酸（KA，5×10⁻⁴ M）的林格氏液的离体青蛙脊髓中，2小时内，γ-氨基丁酸（GABA）激动剂诱导的背根去极化幅度增加。KA灌注使[³H]蝇蕈醇与粗制突触膜的特异性结合增加，且与KA孵育3小时并未增加[³H]蝇蕈醇的结合。在高钾存在的情况下，[³H]GABA从KA处理的脊髓切片中释放出来。KA诱导的背根对GABA超敏反应可能与对初级传入终末的直接作用有关，而非与GABA能神经元的去神经支配有关。