Synthesis of a novel series of (aryloxy)propanolamines: new selective beta 2-blocking agents.
作者信息
Carre M C, Youlassani A, Caubere P, Saint-Aubin-Floch A, Blanc M, Advenier C
出版信息
J Med Chem. 1984 Jun;27(6):792-9. doi: 10.1021/jm00372a016.
PMID:6145801
Abstract
A new family of beta-blocking drugs is described. The originality of the new molecules lies in their functionalized hydrophobic folded structure, the basic part of which contains a benzocyclobutene ring. Excellent beta 2-blocker selectivity has been obtained with some of these compounds. Interestingly, this selectivity was not modified toward beta 1-blocker activity by introduction of the usual beta 1 inducer groups.
摘要
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