温度对吲哚拉明和拉贝洛尔在大鼠肠系膜血管床中α-肾上腺素能受体拮抗效力的影响。
The effect of temperature on the alpha-adrenoceptor antagonist potency of indoramin and labetalol in the rat perfused mesenteric vascular bed.
作者信息
McAdams R P
出版信息
J Pharm Pharmacol. 1984 Sep;36(9):628-9. doi: 10.1111/j.2042-7158.1984.tb04914.x.
Abstract
The effect of reduction in temperature of perfusion from 37 to 27 degrees C and 20 degrees C on the ability of the adrenoceptor antagonists indoramin and labetalol to block pressor responses to noradrenaline in the perfused mesenteric vascular bed of the rat was examined. The results suggest that in rat mesenteric bed, antagonist potency of both agents is increased at low temperatures.
摘要
研究了将灌注温度从37℃降至27℃和20℃对肾上腺素能受体拮抗剂吲哚拉明和拉贝洛尔阻断大鼠肠系膜血管床中去甲肾上腺素升压反应能力的影响。结果表明，在大鼠肠系膜血管床中，两种药物在低温下的拮抗剂效力均增强。
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