儿茶酚胺可增加以恒定速率灌注的离体海蟾蜍（Bufo marinus）肾脏的尿液生成。

Catecholamines increase urine formation in isolated toad (Bufo marinus) kidneys perfused at constant rate.

作者信息

Morris J L

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;79(1):219-25. doi: 10.1016/0742-8413(84)90189-0.

Abstract

Infusion of catecholamines into isolated kidneys of the toad (Bufo marinus) perfused at constant rate, produced increased arterial pressure accompanied by increased glomerular filtration rate, urine formation rate and sodium excretion. These parameters were all increased by arterial infusion of adrenaline or noradrenaline, or by infusion of adrenaline via the renal portal veins. Portal venous pressure increased slightly after arterial or portal infusion of adrenaline, but decreased after arterial infusion of noradrenaline. Estimation of segmental pressure gradients indicated that the efferent glomerular arterioles were selectively constricted by low concentrations of adrenaline or noradrenaline (3 X 10(-9), 3 X 10(-8) mol l(-1)). Higher concentrations of these amines constricted the preglomerular, as well as the postglomerular vasculature. These results demonstrate that the pericytes and/or endothelial cells which form the walls of the efferent arterioles in B. marinus are capable of active contraction.

摘要

以恒定速率灌注蟾蜍（海蟾蜍）的离体肾脏时，注入儿茶酚胺会使动脉压升高，同时肾小球滤过率、尿液生成率和钠排泄增加。通过动脉注入肾上腺素或去甲肾上腺素，或通过肾门静脉注入肾上腺素，这些参数都会增加。动脉或门静脉注入肾上腺素后，门静脉压力略有升高，但动脉注入去甲肾上腺素后，门静脉压力降低。节段压力梯度的估计表明，低浓度的肾上腺素或去甲肾上腺素（3×10⁻⁹、3×10⁻⁸ mol l⁻¹）会选择性地收缩肾小球出球小动脉。这些胺类物质的较高浓度会收缩肾小球前和肾小球后的血管系统。这些结果表明，构成海蟾蜍出球小动脉壁的周细胞和/或内皮细胞能够进行主动收缩。