过氧化氢对星鲨（犬星鲨）晶状体的影响。

Effects of H2O2 on the dogfish (Mustelus canis) ocular lens.

作者信息

Zigman S, Paxhia T, Antonellis B, Waldron W

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;79(1):59-62. doi: 10.1016/0742-8413(84)90163-4.

Abstract

The influence of in vitro exposure of dogfish (Mustelus canis) lenses to H2O2 was studied. Concentrations of H2O2 greater than 10(-4)M caused opacities in the outer cortex of the lens within a few hr. Evidence of protein aggregation within the lens and in extracted lens protein solutions was found. Dithiothreitol inhibits aggregation. Little if any influence of H2O2 was observed on 86Rb exchange of the dogfish lens.

摘要

研究了体外将姥鲨（鼬鲨）晶状体暴露于过氧化氢（H₂O₂）的影响。浓度大于10⁻⁴M的H₂O₂在数小时内会导致晶状体外部皮质出现混浊。在晶状体内部以及提取的晶状体蛋白溶液中发现了蛋白质聚集的证据。二硫苏糖醇可抑制聚集。未观察到H₂O₂对姥鲨晶状体的⁸⁶Rb交换有任何显著影响。