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[周期性重力过载对白化大鼠心肌和骨骼肌肌动球蛋白理化性质及Ca2+反应性的影响]

[Effect of periodic gravitation overloads on the physico-chemical properties and Ca2+ reactivity of actomyosin of the myocardium and skeletal muscles of albino rats].

作者信息

Tikunov B A, Kaifadzhian M A, Oganesian S S

出版信息

Kosm Biol Aviakosm Med. 1984 Sep-Oct;18(5):44-7.

PMID:6151016
Abstract

Under the influence of regular acceleration (5 g for 25 min during 15 days) Mg2+-ATPase activity of native and desensitized actomyosin of the myocardium and femurs of white rats increased. This was in correlation with increases in the rate of actomyosin superprecipitation (Vspp) and in the surface charge of macromolecules. The control animals showed a decrease in the inhibition of Mg2+-ATPase and Vspp of native actomyosin by tropomyosin-troponin. Ca2+ in a concentration of 10(-7) - 10(-4) M stimulated Mg2+-ATPase of native actomyosin of experimental animals by 50% only, but the maximum activation of Vspp was significantly higher than in the controls. It is assumed that these changes tend to increase the efficiency of the actomyosin system.

摘要

在规律性加速作用下(15天内每天25分钟,加速度为5g),白色大鼠心肌和股骨的天然及脱敏肌动球蛋白的Mg2 + -ATP酶活性增强。这与肌动球蛋白超沉淀速率(Vspp)及大分子表面电荷的增加相关。对照动物中,原肌球蛋白 - 肌钙蛋白对天然肌动球蛋白的Mg2 + -ATP酶及Vspp的抑制作用减弱。浓度为10(-7) - 10(-4) M的Ca2 +仅使实验动物天然肌动球蛋白的Mg2 + -ATP酶活性提高50%,但Vspp的最大激活程度显著高于对照。据推测,这些变化倾向于提高肌动球蛋白系统的效率。

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