细胞基因组重组对体外分裂细胞衰老或永生化的影响。
Implications of the reorganization of the cell genome for aging or immortalization of dividing cells in vitro.
作者信息
Macieira-Coelho A
出版信息
Gerontology. 1980;26(5):276-82. doi: 10.1159/000212428.
PMID:6156105
Abstract
Cellular aging or immortalization depends on random reorganization of the cell genome and is determined by chance, intrinsic properties of the cell and environmental factors. The probability of creating a new genetic progressively autonomous program is higher for some cells than for others and is increased by external events that introduce de novo information.
摘要
细胞衰老或永生化取决于细胞基因组的随机重组，由机遇、细胞的内在特性和环境因素决定。对于某些细胞而言，创建一个新的逐渐自主的遗传程序的概率高于其他细胞，并且会因引入全新信息的外部事件而增加。
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