Bosl G J, Kwong R, Lange P H, Fraley E E, Kennedy B J
Cancer Treat Rep. 1980 Feb-Mar;64(2-3):331-4.
A program for treating advanced testicular cancer with vinblastine, bleomycin, and a single dose of cis-dichlorodiammineplatinum(II) was used in an attempt to reduce the toxicity of a 5-day regimen while maintaining a high response rate. In ten previously untreated and six previously treated patients, the complete remission rate was 25%. Toxic reactions were frequent, and there was one drug-related death. This single-dose cis-dichlorodiammineplatinum(II) program is ineffective in the treatment of testicular cancer. Other means for reducing toxicity will have to be considered.
使用长春碱、博来霉素和单剂量顺式二氯二氨铂（II）治疗晚期睾丸癌的方案，旨在降低5天疗程的毒性，同时保持高缓解率。在10例先前未接受治疗和6例先前接受过治疗的患者中，完全缓解率为25%。毒性反应频繁，有1例与药物相关的死亡。这种单剂量顺式二氯二氨铂（II）方案在治疗睾丸癌方面无效。必须考虑其他降低毒性的方法。
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