Amlot P L, Slaney J
Int Arch Allergy Appl Immunol. 1981;64(2):138-45. doi: 10.1159/000232685.
We have found a normal incidence of atopy among patients with Hodgkin's disease (HD). Atopic HD patients had serum IgE levels and allergen specificities similar to those observed in an atopic but otherwise normal population. An atopic family background increased the number of weakly positive allergen responses in otherwise non-atopic HD patients. This effect of atopic background is known to be true for normal healthy subjects. serum IgE was raised in a third of the non-atopic HD patients but they showed neither an increase in allergen specificity nor a more frequent atopic family background than patients with normal IgE. IgE was the most frequently raised immunoglobulin class and was due to its increased synthesis. We concluded that the hyper-IgE which occurs in non-atopic HD patients is distinct from the increase in allergen-specific IgE which occurs in atopy.)
我们发现霍奇金淋巴瘤（HD）患者中特应性疾病的发病率正常。特应性HD患者的血清IgE水平和过敏原特异性与在特应性但其他方面正常的人群中观察到的相似。特应性家族背景增加了原本非特应性HD患者中弱阳性过敏原反应的数量。特应性背景的这种影响在正常健康受试者中也是如此。三分之一的非特应性HD患者血清IgE升高，但与IgE正常的患者相比，他们的过敏原特异性没有增加，特应性家族背景也没有更常见。IgE是最常升高的免疫球蛋白类别，这是由于其合成增加所致。我们得出结论，非特应性HD患者中出现的高IgE与特应性疾病中出现的过敏原特异性IgE增加不同。
