用仓鼠间皮瘤进行的化疗试验10 - 24：对阿扎胞苷、氮丙啶基苯醌、顺铂和甲基苄肼亚硝脲的反应。
Chemotherapeutic trials with hamster mesothelioma 10-24: responses to azacitidine, aziridinylbenzoquinone, cisplatin, and PCNU.
作者信息
Holiat S M, Smith W E, Hubert D D, Davis S
出版信息
Cancer Treat Rep. 1981 Nov-Dec;65(11-12):1113-5.
PMID:6170430
Abstract
Asbestos-induced peritoneal mesothelioma 10-24 serially transplanted in Syrian golden hamsters was used to test responses to seven drugs as single agents. Compared to saline-treated controls, the average survival time increased 51%-85% with azactitidine, 42%-60% with aziridinylbenzoquinone, 43% with cisplatin, and 35%-45% with PCNU. No cures were achieved. Therapeutic responses were not observed with dactinomycin, dianhydroxyanthracenedione, or DTIC.
摘要
将石棉诱导的腹膜间皮瘤在叙利亚金黄地鼠中连续传代10 - 24次后，用于测试七种药物作为单一药剂的反应。与生理盐水处理的对照组相比，阿扎胞苷使平均存活时间增加了51% - 85%，氮丙啶基苯醌增加了42% - 60%，顺铂增加了43%，丙卡巴肼增加了35% - 45%。无一治愈病例。放线菌素、二羟基蒽二酮或达卡巴嗪未观察到治疗反应。
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