Kessler J A, Black I B
Brain Res. 1982 Feb 18;234(1):182-7. doi: 10.1016/0006-8993(82)90485-1.
Factors regulating the putative peptide neurotransmitter, substance P, were examined in the adult rat sympathetic superior cervical ganglion (SCG). Surgical section of the preganglionic nerves resulted in a 55% increase in ganglion content of SP-like immunoreactivity (subsequently termed SP). Treatment with chlorisondamine, which blocks nicotinic ganglionic transmission, also increased SP, reproducing the effects of decentralization. Conversely, treatment with phenoxybenzamine, which reflexly increases sympathetic activity, reduced ganglion SP. Axotomy of the postganglionic nerves did not alter ganglion SP. Finally, treatment of rats as neonates with 6-hydroxydopamine, which selectively destroys principal ganglion neurons, profoundly decreased SP in the adult SCG. Our observations suggest that impulse activity of preganglionic nerves decreases ganglion SP in principal ganglion neurons through a transsynaptic process. Viewed in conjunction with previous work, our studies suggest that transsynaptic stimulation has opposite effects on SP and noradrenergic transmitter characters in the SCG.
在成年大鼠交感神经颈上神经节（SCG）中研究了调节假定的肽类神经递质P物质的因素。节前神经的手术切断导致神经节中P物质样免疫反应性（随后称为P物质）含量增加55%。用阻断烟碱型神经节传递的氯异吲哚铵治疗也增加了P物质，重现了去神经支配的效果。相反，用反射性增加交感神经活动的酚苄明治疗可降低神经节中的P物质。节后神经的轴突切断并未改变神经节中的P物质。最后，新生大鼠用6-羟基多巴胺治疗，该药物选择性地破坏主要神经节神经元，可使成年SCG中的P物质显著减少。我们的观察结果表明，节前神经的冲动活动通过跨突触过程降低主要神经节神经元中的神经节P物质。结合先前的研究来看，我们的研究表明跨突触刺激对SCG中的P物质和去甲肾上腺素能递质特性有相反的影响。
