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铁（II）博来霉素、路易斯碱与DNA之间的相互作用。

Interactions among iron(II) bleomycin, Lewis bases, and DNA.

作者信息

Antholine W E, Petering D H, Saryan L A, Brown C E

出版信息

Proc Natl Acad Sci U S A. 1981 Dec;78(12):7517-20. doi: 10.1073/pnas.78.12.7517.

DOI:10.1073/pnas.78.12.7517
PMID:6174974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC349299/
Abstract

The interaction of sulfur-containing ligands with complexes of Fe(II) bleomycin [Fe(II)Blm] was investigated by comparing DNA strand-scission activity with the structural characteristics of the complex. The bithiazole ring of excess Blm can form intermolecular complexes with Fe(II)Blm and with NO-Fe(II)Blm, and the bithiazole groups of CO-Fe(II)Blm interact with the metal center. This binding can be reversed by glutathione, CO-Fe(II)Blm binds to poly(dA-dT) . poly(dA-dT) via its bithiazole group to change the environment of the Fe2+ ion. Glutathione binds to the CO-Fe(II)Blm-poly(dA-dT) . poly(dA-dT) complex under conditions in which it stimulates DNA strand scission by Fe(II)Blm.

摘要

通过比较DNA链断裂活性与配合物的结构特征，研究了含硫配体与铁（II）博来霉素配合物[Fe（II）Blm]之间的相互作用。过量博来霉素的双噻唑环可与Fe（II）Blm和NO-Fe（II）Blm形成分子间配合物，而CO-Fe（II）Blm的双噻唑基团与金属中心相互作用。这种结合可被谷胱甘肽逆转，CO-Fe（II）Blm通过其双噻唑基团与聚（dA-dT）·聚（dA-dT）结合，从而改变Fe2+离子的环境。在谷胱甘肽刺激Fe（II）Blm导致DNA链断裂的条件下，谷胱甘肽与CO-Fe（II）Blm-聚（dA-dT）·聚（dA-dT）配合物结合。

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本文引用的文献

1
A 1H nuclear relaxation study of the Mn2+ . bleomycin complex. Proximity of the metal to the DNA-binding site.Mn2+·博来霉素复合物的1H核磁共振弛豫研究。金属与DNA结合位点的接近程度。
J Biol Chem. 1981 Feb 10;256(3):1242-7.
2
Bleomycin-A2 complexes with poly(dA--dT): a proton nuclear magnetic resonance study of the nonexchangeable hydrogens.博来霉素-A2与聚（dA--dT）的复合物：非交换氢的质子核磁共振研究
Biochem Biophys Res Commun. 1980 Jan 15;92(1):197-205. doi: 10.1016/0006-291x(80)91539-9.
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Structural studies of of "active complex" of bleomycin: assignment of ligands to the ferrous ion in a ferrous-bleomycin-carbon monoxide complex.博来霉素“活性复合物”的结构研究：在亚铁-博来霉素-一氧化碳复合物中配体与亚铁离子的分配
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5616-20. doi: 10.1073/pnas.76.11.5616.
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Biochem Biophys Res Commun. 1979 Nov 28;91(2):528-33. doi: 10.1016/0006-291x(79)91554-7.
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J Biol Chem. 1979 Nov 10;254(21):10906-12.
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Biochemistry. 1979 Sep 4;18(18):3989-95. doi: 10.1021/bi00585a023.

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