接触抗神经生长因子对成年大鼠和豚鼠感觉神经元的影响。

Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs.

作者信息

Schwartz J P, Pearson J, Johnson E M

出版信息

Brain Res. 1982 Jul 29;244(2):378-81. doi: 10.1016/0006-8993(82)90102-0.

Abstract

Nerve growth factor (NGF) deprivation was produced in adult rats and guinea pigs by immunization against mouse NGF. Exposure of adult animals to anti-NGF had no effect on sensory ganglion neuronal number or size-frequency histograms. However, the substance P content of sensory ganglia, spinal cord and hind paw skin decreased to as great an extent as was seen in animals exposed to anti-NGF in utero. We conclude that NGF has two separate effects on sensory neurons: adult sensory neurons require NGF for normal function whereas developing neurons require NGF for both survival and transmitter expression.

摘要

通过对小鼠神经生长因子（NGF）进行免疫，在成年大鼠和豚鼠中造成NGF缺乏。成年动物接触抗NGF对感觉神经节神经元数量或大小频率直方图没有影响。然而，感觉神经节、脊髓和后爪皮肤中的P物质含量下降程度与在子宫内接触抗NGF的动物中所观察到的一样大。我们得出结论，NGF对感觉神经元有两种不同的作用：成年感觉神经元需要NGF来维持正常功能，而发育中的神经元则需要NGF来实现存活和递质表达。