P物质、生长抑素和神经降压素在人下丘脑的分布。

Distribution of substance P, somatostatin and neurotensin in the human hypothalamus.

作者信息

Langevin H, Emson P C

出版信息

Brain Res. 1982 Aug 19;246(1):65-9. doi: 10.1016/0006-8993(82)90142-1.

Abstract

The distribution of substance P, somatostatin and neurotensin in the human hypothalamus was studied by radioimmunoassay analysis of 11 nuclei and areas within the hypothalamus, in 10 human post-mortem cases. The samples were microdissected according to a recently developed standardized method. Substance P was present in higher concentrations both rostrally in the hypothalamus, and ventrally. Somatostatin was found predominantly in the basal tuberal region, and neurotensin in the anterior hypothalamic area. The chromatographic behaviour of human hypothalamic neurotensin is also presented.

摘要

通过对10例人类尸检病例下丘脑内11个核团和区域进行放射免疫分析，研究了P物质、生长抑素和神经降压素在人类下丘脑的分布情况。样本根据最近开发的标准化方法进行显微解剖。P物质在下丘脑前部和腹侧的浓度较高。生长抑素主要存在于基底结节区，神经降压素则存在于下丘脑前部区域。文中还介绍了人类下丘脑神经降压素的色谱行为。